Glutaraldehyde Cross-Linked Chitosan Polylactic Acid Membrane for Creatinine and Urea Dialysis Applications

Khabibi, Khabibi; Aanisa, Nabila Amalia Izaaz; Prasetya, Nor Basid Adiwibawa; Lusiana, Retno Ariadi

doi:10.22079/jmsr.2025.2053259.1703

Glutaraldehyde Cross-Linked Chitosan Polylactic Acid Membrane for Creatinine and Urea Dialysis Applications

Document Type : Research Paper

Authors

Khabibi Khabibi

Nabila Amalia Izaaz Aanisa

Nor Basid Adiwibawa Prasetya

Retno Ariadi Lusiana

Department of Chemistry, Faculty of Sciences and Mathematics, University of Diponegoro Semarang, Center of Java, Indonesia

10.22079/jmsr.2025.2053259.1703

Abstract

This study synthesized and characterized glutaraldehyde cross-linked chitosan membranes with a blend of polylactic acid (CsGP) and determined the dialysis performance for creatinine and urea. This research was conducted to evaluate the impacts of various glutaraldehyde concentrations (1 [CsGP1], 2 [CsGP2], and 3% [CsGP3]) combined with polylactic acid (at a mass ratio of chitosan to polylactic acid of 1:0.2, on both the physical and functional attributes of the membrane. The physical and chemical characterization of the membrane, including weight and thickness test, swelling, porosity, water uptake, hydrophilicity, tensile strength, flux, FTIR, SEM, and membrane transport for creatinine and urea, was also investigated. The FTIR results demonstrated the successful completion of the CsGP membrane, as evidenced by the appearance of C=N groups resulting from the reaction of chitosan with glutaraldehyde and a shift in the absorption of -OH groups suggests that hydrogen bonds exist between chitosan and polylactic acid. Characterization of the modified membrane showed that glutaraldehyde and polylactic acid could increase the weight and thickness, swelling power, porosity, water absorption, hydrophilicity, and membrane transport ability. The transport of creatinine and urea increased by 81% and 40%, respectively, compared with pure chitosan. These findings suggest that the CsGP membrane may represent a viable option for dialysis and biomedical applications.

Graphical Abstract